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Recent Publictions

J. Bormann, C. Heinze, C. Blum, M. Mentges, A. Brockmann, A. Alder, S. K. Landt, B. R. Josephson, D. Indenbirken, M. Spohn, B. Plitzko, S. Loesgen, M. Freitag, W. Schäfer: Expression of a structural protein of the mycovirus FgV-ch9 negatively affects the transcript level of a novel symptom alleviation factor and causes virus-infection like symptoms in Fusarium graminearum. J. Virol. 2018, DOI: 10.1128/JVI.00326.18

B. Plitzko, S. Loesgen: Measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in culture cells for assessment of the energy metabolism. Bio-protocol 2018, 8(10): e2850. DOI: 10.21769/BioProtoc.2850.

J. E. Parkinson, T. R. Tivey, P. E. Mandelare, D. A. Adpressa, S. Loesgen, V. M. Weis: Subtle differences in symbiont cell surface glycan profiles do not explain species-specific colonization rates in a model cnidarian-algal symbiosis. Front. Microbiol. 2018, 9, 842. DOI: 10.3389/fmicb.2018.00842

P. E. Mandelare, D. A. Adpressa, E. N. Kaweesa, L. N. Zakharov, S. Loesgen: Co-culture of two Developmental Stages of a Marine-derived Aspergillus alliaceus Results in the Production of the Cytotoxic Bianthrone Allianthrone A. J. Nat. Prod. 2018, 18, 1014-1022. DOI: 10.1021/acs.jnatprod.8b00024

B. Plitzko, E. N. Kaweesa, S. Loesgen: The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells. J. Biol. Chem. 2017, 292, 21102-21116. DOI: 10.1074/jbc.M116.774836

D. A. Adpressa, K. Stalheim, P. J. Proteau, S. Loesgen: Unexpected biotransformation of the HDAC inhibitor vorinostat yields aniline-containing fungal metabolites. ACS Chem. Biol. 2017, DOI: 10.1021/acschembio.7b00268

S. Shahzad-ul-Hussan, Mallika Sastry, Thomas Lemmin, Cinque Soto, S. Loesgen, Danielle A. Scott, Jack R. Davison, Katheryn Lohith, Robert O'Connor, Peter D. Kwong, C. A. Bewley: NMR structures and characterization of Man-9 free and complexed with HIV-neutralizing agents. ChemBioChem, 2017, 18, 1-9. doi: 10.1002/cbic.201600665.

D. A. Adpressa, S. Loesgen: Bioprospecting Chemical Diversity and Bioactivity in a Marine Derived Aspergillus terreus. Chem. Biodivers. 2016, 13, 253-259. DOI: 10.1002/cbdv.201500310.

S. Maier, T. Pflüger, S. Loesgen, K. Asmus, E. Brötz, T. Paululat, A. Zeeck, S. Andrade, A. Bechthold: Novel insights into the bioactivity and epoxide formation in mensacarcin by MsnO8. ChemBioChem 2014, 15, 749-756.

A. Kachko*, S. Loesgen*, S. Shahzad-ul-Hussan, W. Tan, I. Zubkova, K. Takeda, F. Wells, S. Rubin, C. A. Bewley and M. E. Major: Inhibition of Hepatitis C Virus by the Cyanobacterial Protein MVL: mechanistic differences between the high- mannose specific lectins MVL, CV-N, and GNA. Mol. Pharmaceutics 2013, 10, 4590-4602. DOI: 10.1021/mp400399b.

M. Pancera, S. Shahzad-ul-Hussan, N. A. Doria-Rose, K. Dai, J. S. McLellan, R. P. Staupe, Y. Yang, B. Zhang, S. Loesgen, M. N. Amin, L.-X. Wang, D. R. Burton, W. C. Koff, G. J. Nabel, J. R. Mascola, C. A. Bewley, P. D. Kwong: Structure of broadly neutralizing antibody PG16 in complex with HIV-1 gp120 V1/V2 domain reveals complex-type N-glycan recognition. Nat. Struct. Mol. Biol. 2013, 20, 804-813.

N. M. Haste, W. Thienphrapa, D. N. Tran, S. Loesgen, P. Sun, S.-J. Nam, P. R. Jensen, W. Fenical, G. Sakoulas, V. Nizet, M. E. Hensler: Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J. Antibiot. 2012, 65, 593–598.

L. Kaysser, P. Bernhardt, S.-J. Nam, S. Loesgen, J. G. Ruby, P. Skewes-Cox, W. Fenical, B. S. Moore: Merochlorins A–D, cyclic meroterpenoid antibiotics biosynthesized from divergent pathways involving vanadium-dependent chloroperoxidases. J. Am. Chem. 2012, 134, 11988-11991.

G. Sakoulas, S.-J. Nam, S. Loesgen, W. Fenical, P. R. Jensen, V. Nizet, M. Hensler: Novel Bacterial Metabolite Merochlorin A Demonstrates in vitro Activity against Multi-Drug Resistant Methicillin-Resistant Staphylococcus aureus. PLoS ONE 7(1): e29439. 2012. doi:10.1371/journal.pone.0029439

A. Edlund, S. Loesgen, W. Fenical, P. R. Jensen: Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola. Appl. Environ. Microbiol. 2011, 77, 5916-5925.

S. Loesgen, T. Bruhn, K. Meindl, I. Dix, B. Schulz, A. Zeeck, G. Bringmann: (+)-Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics. Eur. J. Org. Chem. 2011, 26, 5156-5162.

B. Schulz, S. Draeger, T. E. dela Cruz, J. Rheinheimer, K. Siems, S. Loesgen, J. Bitzer, O. Schloerke, A. Zeeck, I. Kock, H. Hussein, J. Dai, K. Krohn: Screening strategies for obtaining novel, biologically active, fungal secondary metabolites from marine habitats. Botanica Marina 2008, 51, 219-234.

S. Lösgen, J. Magull, B. Schulz, S. Draeger, A. Zeeck: Isofusidienols, Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp. Eur. J. Org. Chem. 2008, 698-703.

S. Lösgen, O. Schlörke, K. Meindl, R. Herbst-Irmer, A. Zeeck: Structure and Biosynthesis of Chaetocyclinones, New Polyketides Produced by an Endosymbiotic Fungus. Eur. J. Org. Chem. 2007, 2191-2196.

S. Lösgen: Isolation and Structure Elucidation of Secondary Metabolites of Fungi associated with marine Algae and Semisynthetic Studies on the Cytotoxic Polyketide Mensacarcin. Book in German. Sierke Verlag Göttingen Göttingen 2007 (ISBN 3-940333-18-6).