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Recent Publictions

J. E. Parkinson, T. R. Tivey, P. E. Mandelare, D. A. Adpressa, S. Loesgen, V. M. Weis: Subtle differences in symbiont cell surface glycan profiles do not explain species-specific colonization rates in a model cnidarian-algal symbiosis. Front. Microbiol. 2018, DOI: 10.3389/fmicb.2018.00842

P. E. Mandelare, D. A. Adpressa, E. N. Kaweesa, L. N. Zakharov, S. Loesgen: Co-culture of two Developmental Stages of a Marine-derived Aspergillus alliaceus Results in the Production of the Cytotoxic Bianthrone Allianthrone A. J. Nat. Prod. 2018, DOI: 10.1021/acs.jnatprod.8b00024

B. Plitzko, E. N. Kaweesa, S. Loesgen: The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells. J. Biol. Chem. 2017, 292, 21102-21116. DOI: 10.1074/jbc.M116.774836

D. A. Adpressa, K. Stalheim, P. J. Proteau, S. Loesgen: Unexpected biotransformation of the HDAC inhibitor vorinostat yields aniline-containing fungal metabolites. ACS Chem. Biol. 2017, DOI: 10.1021/acschembio.7b00268

S. Shahzad-ul-Hussan, Mallika Sastry, Thomas Lemmin, Cinque Soto, S. Loesgen, Danielle A. Scott, Jack R. Davison, Katheryn Lohith, Robert O'Connor, Peter D. Kwong, C. A. Bewley: NMR structures and characterization of Man-9 free and complexed with HIV-neutralizing agents. ChemBioChem, 2017, 18, 1-9. doi: 10.1002/cbic.201600665.

D. A. Adpressa, S. Loesgen: Bioprospecting Chemical Diversity and Bioactivity in a Marine Derived Aspergillus terreus. Chem. Biodivers. 2016, 13, 253-259. DOI: 10.1002/cbdv.201500310.

S. Maier, T. Pflüger, S. Loesgen, K. Asmus, E. Brötz, T. Paululat, A. Zeeck, S. Andrade, A. Bechthold: Novel insights into the bioactivity and epoxide formation in mensacarcin by MsnO8. ChemBioChem 2014, 15, 749-756.

A. Kachko*, S. Loesgen*, S. Shahzad-ul-Hussan, W. Tan, I. Zubkova, K. Takeda, F. Wells, S. Rubin, C. A. Bewley and M. E. Major: Inhibition of Hepatitis C Virus by the Cyanobacterial Protein MVL: mechanistic differences between the high- mannose specific lectins MVL, CV-N, and GNA. Mol. Pharmaceutics 2013, 10, 4590-4602. DOI: 10.1021/mp400399b.

M. Pancera, S. Shahzad-ul-Hussan, N. A. Doria-Rose, K. Dai, J. S. McLellan, R. P. Staupe, Y. Yang, B. Zhang, S. Loesgen, M. N. Amin, L.-X. Wang, D. R. Burton, W. C. Koff, G. J. Nabel, J. R. Mascola, C. A. Bewley, P. D. Kwong: Structure of broadly neutralizing antibody PG16 in complex with HIV-1 gp120 V1/V2 domain reveals complex-type N-glycan recognition. Nat. Struct. Mol. Biol. 2013, 20, 804-813.

N. M. Haste, W. Thienphrapa, D. N. Tran, S. Loesgen, P. Sun, S.-J. Nam, P. R. Jensen, W. Fenical, G. Sakoulas, V. Nizet, M. E. Hensler: Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J. Antibiot. 2012, 65, 593–598.

L. Kaysser, P. Bernhardt, S.-J. Nam, S. Loesgen, J. G. Ruby, P. Skewes-Cox, W. Fenical, B. S. Moore: Merochlorins A–D, cyclic meroterpenoid antibiotics biosynthesized from divergent pathways involving vanadium-dependent chloroperoxidases. J. Am. Chem. 2012, 134, 11988-11991.

G. Sakoulas, S.-J. Nam, S. Loesgen, W. Fenical, P. R. Jensen, V. Nizet, M. Hensler: Novel Bacterial Metabolite Merochlorin A Demonstrates in vitro Activity against Multi-Drug Resistant Methicillin-Resistant Staphylococcus aureus. PLoS ONE 7(1): e29439. 2012. doi:10.1371/journal.pone.0029439

A. Edlund, S. Loesgen, W. Fenical, P. R. Jensen: Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola. Appl. Environ. Microbiol. 2011, 77, 5916-5925.

S. Loesgen, T. Bruhn, K. Meindl, I. Dix, B. Schulz, A. Zeeck, G. Bringmann: (+)-Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics. Eur. J. Org. Chem. 2011, 26, 5156-5162.

B. Schulz, S. Draeger, T. E. dela Cruz, J. Rheinheimer, K. Siems, S. Loesgen, J. Bitzer, O. Schloerke, A. Zeeck, I. Kock, H. Hussein, J. Dai, K. Krohn: Screening strategies for obtaining novel, biologically active, fungal secondary metabolites from marine habitats. Botanica Marina 2008, 51, 219-234.

S. Lösgen, J. Magull, B. Schulz, S. Draeger, A. Zeeck: Isofusidienols, Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp. Eur. J. Org. Chem. 2008, 698-703.

S. Lösgen, O. Schlörke, K. Meindl, R. Herbst-Irmer, A. Zeeck: Structure and Biosynthesis of Chaetocyclinones, New Polyketides Produced by an Endosymbiotic Fungus. Eur. J. Org. Chem. 2007, 2191-2196.

S. Lösgen: Isolation and Structure Elucidation of Secondary Metabolites of Fungi associated with marine Algae and Semisynthetic Studies on the Cytotoxic Polyketide Mensacarcin. Book in German. Sierke Verlag Göttingen Göttingen 2007 (ISBN 3-940333-18-6).